Stringent Complete Response (sCR) of Multiple Myeloma or Plasma Cell Leukemia

Stringent complete response (sCR) of multiple myeloma or plasma cell leukemia is characterized by complete response plus: normal free light chain ratio, and absence of clonal cells in the bone marrow by immunohistochemistry or immunofluorescence (confirmation with repeat bone marrow biopsy not needed). (Presence and/or absence of clonal cells is based upon the kappa/lamda ratio. An abnormal kappa/lambda ratio by immunohistochemistry and/or immunofluorescence requires a minimum of 100 plasma cells for analysis. An abnormal ratio reflecting the presence of an abnormal clone is kappa/lambda of > 4:1 or < 1:2.). Stringent complete response requires two consecutive assessments made at any time before the institution of any new therapy, and no known evidence of progressive or new bone lesions if radiographic studies were performed; radiographic studies are not required to satisfy stringent complete response requirements. (NCI Thesaurus)

YOU MAY ALSO LIKE

String

An expression consisting of a linear sequence of symbols (characters or words or phrases).

Stridor

A symptom resulting from laryngeal obstruction. It is characterized by a high pitched breathing sound.

Striatin

Striatin (780 aa, ~86 kDa) is encoded by the human STRN gene. This protein may play a role in calcium-mediated signaling. …

Striated Muscle Tissue

Striated muscles are appendicular and axial muscles typically connected at either or both ends to the bony skeleton of the body. …

Striated Muscle Cell

A cylindrical multinucleated cell containing contracting myofibrils, across which run transverse light and dark areas, enclosed in a delicate plasma membrane. …

Striae

Parallel red lines of stretched skin which eventually become whitish. Pregnancy, weight gain and corticosteroids usage are predisposing conditions.